Using chips with only one tip ensures the quality of each individual measurement and is at the same time the most cost-efficient solution. The reason for this is that each patched cell has its individual cycle times, a fact that requires each patch process to be fully independent from the others. Imagine ten manual patch-clampers sitting in one room and being forced to start their experiments always in synchrony, whoever fails has to wait. You soon will have a postdoc rebellion! The "BatchSize ONE" principle simply means getting most out of your resources.
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