ION CHANNEL SCREENING SERVICE
GLP and non-GLP

Automated and Manual Patch Clamp Screening

Cytocentrics ion channel screening service is reliable, time-efficient and focused on premium data quality. Our emphasis on high data quality eliminates the risk of identifying a compound as false negative or false positive, and thus minimizes the risk of losing time and money in the drug development process.
Cytocentrics has the necessary experience and know-how in the area of ion channel screening and assay development.

hERG SAFETY SCREENING SERVICE

Important drugs have been withdrawn from the market due to their blocking effects on the hERG channel, leading to life threatening arrhythmias in patients (acquired LQTS). This prompted regulatory agencies to require preclinical testing of all pharmaceuticals to exclude unwanted side effects due to hERG channel inhibition. Cytocentrics determines potential blocking effects of drug candidates using the patch clamp technique.

Cytocentrics hERG Safety Screening Service includes:

• Study design according to ICH guideline S7B. 
• GLP or non-GLP compliant.
• Whole cell patch clamp recordings.
• IC 50 determination from hERG tail current.
• Use of validated and quality assured Instant Cells.
• Repetitive measurements for each compound concentration.
• Positive and negative control experiments.
• Full scientific report.
  

ION CHANNEL SCREENING SERVICE AND ASSAY DEVELOPMENT

Cytocentrics has the necessary experience and expertise in the area of ion channel screening and assay development. We perform screening studies against the targets:

• K_v1.3
• K_v1.5
• Other ion channels on request
  

We also offer patch clamp studies on transiently transfected cells.

Feel free to contact us for advice. Our experts will discuss with you all options available and will recommend the best study design for your purpose.

What we do for outstanding data quality:

1. Multiple screening platforms for ion channel research
2. Handling of test substances
3. Quality assured cells
4. Good Laboratory Practise (GLP)

Contact:

Do you have any special requirements? As every question is different, we always provide a tailor-made offer. Please contact our experts for detailed information.